The Bioscan, 1(1-4) 063-67,2006
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
OXALIS CORNICULATA (WHOL PLANT) EXTRACTS EXHIBIT
ESTROGENIC ACTIVITIES IN WISTAR STRAIN ALBINO RATS
SHARANGOUDA AND SARASWATI B. PATIL*
Reproductive Biology Laboratory Department of Zoology,
Gulbarga University, Gulbarga - 585106, Karnataka, India
Email: sharanjpatil@gmail.com
KEY WORDS

Oxalis corniculata
Extrogenic Activity
ethnyl estradial
Rat
Uterus



Received on: 08.10.2006

Accepted on: 18.12.2006


*Corresponding
 Author
ABSTRACT

Studies are conducted to determine estrogenic/antiestrogenic activities of petroleum ether and ethanol extract of Oxalis corniculata whole plant. Both the extract at the dose level of 10 and 20 mg/100mg body weight were administrated for 7 days to ovariectomised rats, along with or without 1mg ethinyl estradiol. Suitable controls were maintained. The extract treated rats exhibited extragonic effect that include increase in uterine weight and vaginal epithelial cell cornification. The micrometric measerments of uterus and its components were increased and gland indicate high secretary activity. When the above extract were tested for estrogenic activity in 30 days old immunature rat the above estrogenic activity were confirmed along with early opening of vagina. Hence, the results indicate the potent estrogenic nature of petroleum ether and ethanol extracts of Oxalis corniculata whole plant among which the former is more effective.