The Bioscan, 2 (2) 077-81,2007
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
EFFECTS OF ADDROGRAPHIS PANICULATA (NEES.) ON ARSENIC- 
INDUCED ALTERED GLUCOSE HOMEOSTASIS AND OXIDATIVE
IMPAIRMENT IN PANCREAS OF SWISS MICE
MANDAVA V. RAO* AND DIMPLE, M. DMORE**
*Department of Zoology, School of Science.
Gujrat University,Ahmedabad - 380 009, Gujrat, INDIA
**Department of Zoology, Bhavan's R.A. College of Science, Ahmedabad,Gujrat- INDIA
E-mail: zooldeptgu@satyam.co.in

KEY WORDS

Arsenic
Oxidative stress
Andrographis
paniculata
Pancreas
Mice


Received on: 11.12.2006

Accepted on: 02.02.2007



*Corresponding
 Author

ABSTRACT

The effect of Andrographis paniculata (Nees.) on arsenic-induced changes in biochemical and cellular antioxident sytem was studies in adult female mice. Daily oral administration of arsenic trioxide (0.5 and 1.0mg/kg b.w) for 30days induced a significant increase in blood glucose level which was associated with impaired glucose tolrence. Arsenic treatment also resulted in elevated level panreatic tissue specific makers such as activities of amylase and lipase in serum indicating pancreatic dysfunction. Interestingly, this biochemical dysfuntion was accompanied by a marked dose related enchancement of lipid peroxidation indicating significant induction of oxidative damage. Additional evidence such as deletion in reduced gluatathione levels and alterations in enzymic antioxidant defences like superoxide dismutase, catalase and glutathione peroxidase in pancreas suggested induction of oxidative stress. Concomitant administration of Adrographis paniculata (50 mg/kg b.w.) with arsenic significant restored all these parameters. These results suggest that Adrographis paniculata is capable to reducing arsenic-induce cellular oxidative and inflammatory changes in pancreas.