The Bioscan, 2 (2) 089-094,2007
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
DESIGN AND EVALUATION OF SALBUTAMOL SULPHATE BUCCAL PATCH
M.H. DEHGHAN*, S.R. PARAKH**, M.S. WANI**, S.A. POLSHETTIWAR** AND V.V. PANDE**
Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad - 431 001. **MAEER's Maharashtra Institue of Pharmacy, S. No. 124, MIT Campus, Paud Road, Kothrud, Pune - 411 038. E-mail: mhdehghan@hotmail.com

KEY WORDS

Buccal patches
Salbutamol
Sulphate
Mucoadhesive
Percentage swelling
in-vitro release


Received on:11.11.2006

Accepted on: 13.01.2007



*Corresponding
 Author
ABSTRACT

Mucoadhesive patches for delivery of salbutalmol sulphate were prepared using hydroxypropylmethylcelluose K4M, hydroxymethylcelluose and carbopol 934P. Gylcerine was used as plasticizer. Mucoadhesive strenght, % swelling, surface pH, film thikness and folding edurance were determined for pain patches. The results of showed Mucoadhesive strength of hydroxypropylmethylcelluose K4M plain and hydroxypropylmethylcelluose K4M combination polymeric patches greater than hydroxyethylecellulose plain and hydroxyethylecellulose combination polymeric patches. It was found that mucoadhesive strength increases with the increase in concentration of carbopol. Percent swelling of patches increase with time and with an increase in concentration of hydrophilic polymer. Incorporation of carbopol increase percent swelling. Percent swelling showed a direct relationship with mucoadhesive strength. The folding endurance of the polymeric patch was found to be 79 to 138. The surface pH of the film was found to be in region of neutral pH. The mean film thickness of the buccal polymeric patches with an increase in the amount of polymer. Drug content uniformity values of Salbutamol sulphate buccal patch were observed to be between 100.18% and 99.18% of the labelled amount. In-vitro release studies of salbutamol sulphate buccal patches showed decrease in percent release with an increase in the amount of polymer. The buccal patches of salbutamol sulphate were found to be stable at 75 +/- 5% RH 45 +/- 2°C when stored for 24 weeks.