The Bioscan, 2 (4): 275-278,2007
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
BIOCHEMICAL AND HISTOPATHOLOGICAL ALTERATIONS IN LUNG OF RATS 
FALLOWING EXPOSURE TO  MICROBIAL PESTICIDE (HALT)
MANGALA B. KARLEKAR (BHAMBURKAR)
P.G. Department of Zoology,
S.G.B. Amravati University, Amravati - 444 602, Maharashtra, INDIA.
E-mail: mangalakarlekar@yahoo.co.in

KEY WORDS

Microbial pesticide
B. thuringiensis Insecticidal crystal protein
Received on: 11.04.2007 Accepted on: 19.06.2007 *Corresponding Author

ABSTRACT

Microbial - based pesticides are considered to be an effective substitute to chemical pesticides in agriculture environment. Microbial pesticides are known as safe and ecofriendly, however, there is a need to confirm it as their use is increasing day by day throughout the world in agriculture practice . Bt produces a parasporal inclusion body during sporulation usually referred to as the insecticidal crystal proteins (ICP) or delta endotoxin . These crystals are pathogenic to large number of insects, particularly to those belonging to order lepidoptera.Though the biopesticides like Halt (bacterial formulation) are widely used throughout the world, they will pose potential danger to Non- target animals. After exposing the male rats to Halt for 90 days, the lungs appeared badly affected showing sever emphysema, sever alveolar congestion with their lumen filled with proteinaceous fluid while females exhibited constricted lung alveoli and hydropic degeneration of interstitial tissue and significant elevation in lung biochemicals, the enzymes like GOT and LDH whereas depletion in ATPase, protein and glycogen.