The Bioscan, 2 (4): 301-303, 2007
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
STUDY OF OXIDATIVE STRESS IN DIFFERENT TISSUES OF RATS IN DIVERSE 
THYROID STATES
A. P. DEWANI*, C. G. HALANI, M. K. KALE, K. P. BHUSARI, S. N. UMATHE**
Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur - 441 110, INDIA
**Dept of Pharmaceutical Sciences, R.T.M. Campus, Amravati Road, Nagpur - 441 110, INDIA
E-mail: anildewani007@gmail.com

KEY WORDS
Hypothyroidism 
Hyperthyroidism 
Oxidative stress


Received on: 21.04.2007

Accepted on: 17.07.2007



*Corresponding
 Author

ABSTRACT

Thyroid dysfunction and concurrent changes in oxidative stress bring about pathological changes in different organs of the body. The aim of the present study was to examine how experimental hypothyroidism and hyperthyroidism affected oxidative stress in different tissues of Sprague Dawley rats. Oxidative stress was determined in different tissues like plasma, thyroid, heart, muscle, and liver in diverse thyroid state. Parameters of oxidative stress showed that the level of malondialdehyde (MDA) in hypothyroid rats was less as compared to control animals in all tissues. Contrary to this, it was significantly higher during hyperthyroidism. The activity of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), and contents of reduced glutathione (GSH) were almost same in hypothyroid state, as compared to control, where as, in hyperthyroid rats these enzymes levels were decreased significantly. All these findings revealed more oxidative stress in hyperthyroid state in all tissues. Results of the study demonstrated that hypothyroidism reduced oxidative stress whereas hyperthyroidism increased oxidative stress in different tissues of rats.