The Bioscan, 2 (4): 305-310, 2007
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
POST-COITAL ANTIFERTILITY ACTIVITY OF CITRUS MEDICA SEEDS
SHARANGOUDA AND SARASWATI B. PATIL*
Reproductive Biology Laboratory,
Department of Zoology, Gulbarga University, Gulbarga - 585 106, Karnataka, INDIA
E-mail: sharanjpatil@gmail.com

KEY WORDS
Citrus medica
Antifertility
Anti-implantation
Pregnancy
Estrogenic Received on: 22.04.2007 Accepted on: 27.08.2007 *Corresponding Author

ABSTRACT

Among the citrus species, Citrus medica (Rutaceae) is native of North region of Karnataka, India. Petroleum ether, benzene and ethanol extracts of Citrus medica seeds were investigated for antifertility activity in female albino rats at the dose level of 200 and 400mg/kg body weight. The extracts were tested for anti-implantation, pregnancy interruption, estrogenic activities and phytochemical screening.. Of these three extracts, the petroleum ether extract was found to be the most effective in causing anti-implantation and pregnancy interruption activities. The petroleum ether extract was found to possess estrogenic activity when tested in immature ovariectomised female albino rats. The adverse effects on fertility are reversible upon withdrawal of the extract treatment. After subjecting to preliminary phytochemical screening, the petroleum ether extract showed positive tests for alkaloids, glycosides, amino acids and proteins, flavonoides and fatty acids.