The Bioscan, 3 (1) 39-42, 2008
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
QSAR STUDIES OF SOME HETEROCYCLIC ANALOGS OF THIADIAZOLIDINONES 
AS GLYCOGEN SYNTHASE KINASE 3-BETA INHIBITORS
 
A.M. KUDAL*, S.A. POLSHETTIWAR AND M.S. WANI
MAEER’S, Maharashtra Institute of Pharmacy, M.I.T. Campus, 
Kothrud, Pune  - 411 038 (M. S.), INDIA
E-mail: anand_kudal@yahoo.com
 

KEY WORDS

QSAR
Glycogen synthase kinase
3-beta inhibitors 
Thiadiazolidinones


Received on: 21.06.2007

Accepted on: 29.12.2007



*Corresponding
 Author
 

ABSTRACT

In the present study, all computational work was carried out by performing a 2D and 3D structure activity relationship on one of the series of substituted thiadiazolidinones as Glycogen Synthase Kinase 3-beta inhibitors. Various physicochemical parameters were calculated, using C.S. Chem office software. Quantitative structure activity models were generated for glycogen synthase kinase -3 beta inhibitory activity using stepwise, sequential multiple regression analysis. Statistically significant models were obtained. The studies indicated that the activity is dependent on structural and electronic descriptors, that is substitution or structural changes in the lead nucleus could yield potent glycogen synthase kinase -3 beta inhibitors.