The Bioscan, 3(2): 151-154, 2008
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
COLON TARGETED HESPERIDINE DELIVERY SYSTEM USING pH AND 
TIME DEPENDENT POLYMERS
V.K. KHAPARDE, A. ROY*, M.K. KALE, V.B. MATHUR AND K.P. BHUSARI
Sharad Pawar College of Pharmacy,
Wanadongri, Hingna Road, Nagpur - 441 110 (M.S.), INDIA
E-mail: roypharma@rediffmail.com

KEY WORDS
Hesperidine 
Hydroxypropylmethyl cellulose (HPMC) Enteric coated polymer
Received on: 03.02.2007 Accepted on: 07.05.2007 *Corresponding Author

ABSTRACT

The colonic targeted drug delivery system was formulated using superdisintegrants and combination of polymers as coating agent. Hesperidine which is used as an anticancer drug for colon cancer was selected as a model drug. The hesperidine tablets were initially coated with hydroxy propyl methyl cellulose (HPMC) followed by different grades of Eudragit (Eudragit L100, Eudragit S100 and Eudragit FS 30D) as enteric coating polymer or pH dependent polymers which prevent any release of the drug initially during the transit of tablet through stomach. On reaching the intestine this coat dissolve slowly exposing the HPMC coat to the intestinal fluid, which was used as the time dependent coat. Thus, the combination of this polymer retard the release of hesperidine desirably. Presence of sodium starch glycolate (SSG) as super disintegrant provided pulsatile release of hesperidine in colon, as evident by the release from 25.30% to 68.40% between 6 and 7 hrs.