The Bioscan, 3(2): 177-181, 2008
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
THERAPEUTIC EFFICACY OF TINOSPORA CORDIFOLIA MIERS STEM 
EXTRACT IN HIGH FAT FED TYPE II DIABETES INDUCED WISTAR RAT
MOHAMMED ABDULLAH Al ERYANI AND PRAKASH R. NAIK
Endocrinology Laboratory, Department of Zoology,
University of Mysore, Mysore - 570 006. Karnataka, INDIA
E-mail: prakashrnaik@yahoo.co.in

KEY WORDS
Type II diabetes 
T. cordifolia
Insulin
Cholesterol
Triglyceride
Received on: 09.10.2007 Accepted on: 06.02.2008 *Corresponding Author

ABSTRACT

The objectives of the present investigation were to develop the animal model resembling closely the type II diabetes of human beings and to verify whether the treatment with T. cordifolia Miersstem extract will alleviate the same. Experimental animals were grouped in to control, diabetic control and diabetic group treated with 100 mg/kg/day and 200 mg/kg/day treatment with T. cordifolia stem extract. Plasma glucose, glycosylated haemoglobin, triglycerides, cholesterol, LDL, VLDL, and blood urea were elevated in diabetic group where as HDL and insulin levels decreased. The levels of all the above parameters were restored to control group level at treatment with T. cordifolia stem extract. Mechanism by which type II diabetes is alleviated has been discussed.