The Bioscan, 4(2): 209-216, 2009
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
USE OF BIOADHESIVE POLYMERS IN CONTROLLED DRUG DELIVERY SYSTEM
A. A. ROY*, V. B. MATHUR, M. K. KALE, U. D. SHIVHARE, AND K. P. BHUSARI
Sharad Pawar College of Pharmacy, Wanadongri,
Hingna Road, Nagpur - 441 110 (M.S.), INDIA
E-mail: roypharma@rediffmail.com

KEY WORDS
Bioadhesion 
Bioadhesive polymer
Controlled release Drug delivery
Received on: 08.09.2008 Accepted on: 21.02.2009 *Corresponding Author

ABSTRACT

Bioadhesion is the process whereby synthetic and natural macromolecules adhere to mucosal surfaces in the body. If these materials are then incorporated into pharmaceutical formulations, drug absorption by mucosal cells may be enhanced or the drug released at the site for an extended period of time. The mechanism of bioadhesion is the result of a number of different physicochemical interactions. Biological bioadhesive, such as plant lectins, show specific interactions with cell surfaces and mucin and are seen as the ‘second generation’ bioadhesives. Bioadhesive systems for drug administration via the buccal and nasal cavities are nearing the market; in the case of nasal bioadhesion, bioadhesive micro-particles are used. A bioadhesive formulation for drug administration to the vagina is in use. The gastrointestinal tract is proving a more difficult site because of the rapid turnover of mucus, and relatively constant transit time, but intensive research is in progress. Micro and nano-particles, coated with either bioadhesive polymers or specific biological bioadhesives, are showing some promise, but will require considerable research and development before reaching the market.