The Bioscan, 4(2): 241-245, 2009
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
ANTIHYPERGLYCEMIC AND ANTIHYPOLIPIDEMIC EFFECTS OF ZINGIBER 
OFFICINALE ETHANOLIC EXTRACT IN STREPTOZOTOCIN INDUCED 
DIABETIC RATS
K. R. SHANMUGAM, CH RAMAKRISHNA, K. MALLIKARJUNA1 AND K. SATHYAVELU REDDY*
Division of Molecular Biology and Exercise Physiology, Department of Zoology,
Sri Venkateswara University, Tirupati - 517 502, A. P., India
1Exercise Biochemistry Lab., Taipei Physical Education College, Taipei City - 111 53, TAIWAN
E-mail: ksreddy2008@hotmail.com

KEY WORDS
Ginger
Diabetes
Glucose
MDA
Rats
Received on: 18.02.2009 Accepted on: 27.05.2009 *Corresponding Author

ABSTRACT

The use of herbal medicines by patients with chronic medical illness like diabetes mellitus is on the increase. This study aims to investigate ginger ethanolic extract for antihyperglycaemic and antihyperlipidaemic effects in diabetic rats induced by streptozotocin. Its effect was compared with that of glibenclamide, a reference antidiabetic drug. The wistar strain male albino rats were the tested species. Diabetic animals were treated orally with ginger (200 mg/kg body weight) once a day for 30 days. The blood glucose levels and body weight changes were regularly observed. After 30 days the kidney tissues are isolated and measured the MDA, lactate and glycogen levels were measured. The ginger extract shows a significant (p<0.001) reduction in levels of blood glucose, MDA, glycogen and lactate. It also showed a significant increase in body weight levels. The study suggests that phytochemicals present in ginger play an important role in suppressing the elevated lipid profile in diabetes and may be useful for the prevention and/or early treatment of diabetes-associated hyperglycemia.