The Bioscan, 4(2): 251-255, 2009
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
FORMULATION AND EVALUATION OF FLOATING CONTROLLED DRUG 
DELIVERY SYSTEM OF CINNARIZINE
A. V. BHALERAO*, P. D. RISWADKAR, S. V. SHIROLKAR AND A. D. DESHPANDE
Department of Pharmaceutics,Pad. Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research,
Pimpri, Pune - 411 018, INDIA
E-mail: aparnavb@rediffmail.com

KEY WORDS
Floating drug 
Delivery system 
Methocel
Xanthan gum
Direct compression Cinnarizine
Received on: 13.11.2008 Accepted on: 27.03.2009 *Corresponding Author

ABSTRACT

The objective of the present investigation was to develop floating drug delivery system of cinnarizine using direct compression method. Various grades of polymers (Methocel K4M, Methocel K15M, Methocel K100 - LV and Xanthan Gum) were used separately in different concentrations for the formulation of this system. Sodium bicarbonate was used as a gas generating agent. Tablets were prepared by physical blending of cinnarizine, polymers (in varying ratios) and other excipients and then compressed on Rotary compression machine (Minipress – II, Karnavati, Ahmadabad, India) .The formulations were optimized on the basis of in vitro buoyancy and in vitro drug release in 0.1N HCl. The tablet remained afloat for more than 11 hrs in the release medium. Sodium bicarbonate 55mg was necessary to remain buoyant without causing disintegration of tablet. The investigation describes the influence of content and viscosity of polymers on drug release. As content and viscosity of polymer increased the drug release retarded. The dissolution data was fitted into zero order, first order, Matrix and Korsemeyer Peppas model. The formulations followed zero order release. So, it was concluded that drug release followed anomalous diffusion to case II transport mechanism and which was mainly dependent on viscosity and content of polymer. The results of the current study clearly indicate, the cinnarizine floating drug delivery system can be formulated.