The Bioscan, 4(2): 251-255, 2009 An International Quarterly Journal of Life Sciences web site: www.thebioscan.in
FORMULATION AND EVALUATION OF FLOATING CONTROLLED DRUG DELIVERY SYSTEM OF CINNARIZINE
A. V. BHALERAO*, P. D. RISWADKAR, S. V. SHIROLKAR AND A. D. DESHPANDE
KEY WORDS Floating drug Delivery system Methocel
objective of the present investigation was to develop floating drug delivery
system of cinnarizine using direct compression method. Various grades
of polymers (Methocel K4M, Methocel K15M, Methocel K100 - LV and Xanthan
Gum) were used separately in different concentrations for the formulation
of this system. Sodium bicarbonate was used as a gas generating agent.
Tablets were prepared by physical blending of cinnarizine, polymers (in
varying ratios) and other excipients and then compressed on Rotary compression
machine (Minipress – II, Karnavati, Ahmadabad, India) .The formulations
were optimized on the basis of in vitro buoyancy and in vitro
drug release in 0.1N HCl. The tablet remained afloat for more than 11
hrs in the release medium. Sodium bicarbonate 55mg was necessary to remain
buoyant without causing disintegration of tablet. The investigation describes
the influence of content and viscosity of polymers on drug release. As
content and viscosity of polymer increased the drug release retarded.
The dissolution data was fitted into zero order, first order, Matrix and
Korsemeyer Peppas model. The formulations followed zero order release.
So, it was concluded that drug release followed anomalous diffusion to
case II transport mechanism and which was mainly dependent on viscosity
and content of polymer. The results of the current study clearly indicate,
the cinnarizine floating drug delivery system can be formulated.