The Bioscan, 4(4): 577-580, 2009
An International Quarterly Journal of Life Sciences
web site: www.thebioscan.in 
HEPATOPROTECTIVE EFFECT OF HIFECTERES ISORA FRUITS EXTRACT ON 
STREPTOZOTOCIN INDUCED DIABETIC RATS
A. BOOPATHY RAJA, C. ELANCHEZHIYAN* AND S. SETHUPATHY1 
Department of Zoology, Annamalai University, Annamalainagar - 608 002, T. N., INDIA
1Division of Biochemistry, Rajah Muthiah Medical College and Hospital,
Annamalai University, Annamalainagar - 608 002, T. N. INDIA
E-mail: chezhiyan6@gmail.com


KEY WORDS
Hepatoprotective effect 
Helicteres isora
Liver function test Streptozotocin
Diabetes mellitus
Received on: 11.07.2009 Accepted on: 21.11.2009 *Corresponding Author

ABSTRACT

In the present investigation, an attempt has been made to test the hepatoprotective efficacy of the herbal plant Helicteres isora Fruit Extract (HiFE) on streptozotocin induced diabetic rats. The diabetic rats showed increased activity of ALP, AST, ALT and bilirubin both in serum and liver tissues. The herbal Helicteres isora fruit extract treated diabetic rats showed marked restoration in the activity of ALP, AST, ALT and bilirubin when compared with normal rats. Liver weight decreased in diabetic rats whereas the herbal extract treated diabetic rats maintained the liver weight as that of normal rats. The total protein content in serum and liver were also maintained by the herbal extract treated diabetic rats when compared to diabetic control rats. The hepatoprotective effect of Helicteres isora fruit extract was compared with the standard drug glibenclamide.